abstract：:Bullous pemphigoid (BP) is a chronic debilitating autoimmune blistering disease that frequently occurs in the elderly population. Previous studies have suggested a high morbidity and mortality associated with BP. However, relatively few studies have investigated prognostic factors of BP mortality, and they showed cons...

journal_title：Archives of dermatological research

authors： Liu YD,Wang YH,Ye YC,Zhao WL,Li L

更新日期：2017-07-01 00:00:00

abstract：:This study uses light and electron microscopes to gain a better knowledge of the interactions of calcium hydroxylapatite filler with the connective tissue of the skin and the modifications of the human deep dermis, after 2 months of treatment. Some morphological evidences of this observational study of filler treated ...

journal_title：Archives of dermatological research

authors： Zerbinati N,D'Este E,Parodi PC,Calligaro A

更新日期：2017-07-01 00:00:00

abstract：:Recent studies revealed the cooperation between peroxisome proliferator-activated receptor gamma (PPARγ) and α-MSH signaling, which results in enhanced melanogenesis in melanocytes and melanoma cells. However, the agonists of PPARα, such as fenofibrate, exert depigmenting effect. Therefore, we aimed to check how the P...

journal_title：Archives of dermatological research

authors： Grabacka M,Wieczorek J,Michalczyk-Wetula D,Malinowski M,Wolan N,Wojcik K,Plonka PM

更新日期：2017-04-01 00:00:00

abstract：:The pathogenicity of Mycobacterium ulcerans (Buruli ulcer) is closely associated with the secretion of exotoxin mycolactone. The cytotoxicity of mycolactone has been linked to its apoptogenic activity. We explored if low mycolactone concentrations, which are not able to induce apoptosis, can influence other essential ...

journal_title：Archives of dermatological research

authors： Graziola F,Colombo E,Tiberio R,Leigheb G,Bozzo C

更新日期：2017-04-01 00:00:00

abstract：:Nephrogenic systemic fibrosis (NSF) is a disease characterized by fibrosis of the systemic organs in patients with renal failure. Following the findings of recent epidemiological studies and the finding of gadolinium (Gd) in the skin tissue of NSF patients, it is now definitely known that the use of Gd contrast agents...

journal_title：Archives of dermatological research

authors： Ozawa Y,Hayashi S,Hamasaki Y,Hatamochi A

更新日期：2016-12-01 00:00:00

abstract：:Skin aging is a natural process of the human body that may be accelerated due to extrinsic causes. Libidibia ferrea, popularly known as jucá, is a small tree, which possesses an abundant phenolic composition with potential antioxidant and enzymatic inhibition activities. Thus, this work aimed to investigate the anti-w...

journal_title：Archives of dermatological research

authors： Pedrosa TD,Barros AO,Nogueira JR,Fruet AC,Rodrigues IC,Calcagno DQ,Smith MA,de Souza TP,Barros SB,de Vasconcellos MC,Silva FM,Koolen HH,Maria-Engler SS,Lima ES

更新日期：2016-11-01 00:00:00

abstract：:Studies have identified increased prevalence of vitamin D deficiency in patients with alopecia areata (AA), an autoimmune disease characterized by hair loss, but none have prospectively examined vitamin D status and incident AA. In 55,929 women in the Nurses' Health Study (NHS), we prospectively evaluated the associat...

journal_title：Archives of dermatological research

authors： Thompson JM,Li T,Park MK,Qureshi AA,Cho E

更新日期：2016-11-01 00:00:00

abstract：:The study aimed at detecting differentially expressed proteins in the stratum corneum of dandruff versus non-dandruff scalps to better understand dandruff aetiology. iTRAQ-based quantitative proteomic analysis revealed a total of 68 differentially expressed biomarkers. A detailed analysis of their known physiological ...

journal_title：Archives of dermatological research

authors： Cavusoglu N,Delattre C,Donovan M,Bourassa S,Droit A,El Rawadi C,Jourdain R,Bernard D

更新日期：2016-11-01 00:00:00

abstract：:Scleroderma is a heterogeneous disease with a complex etiology. As more information is gained about the underlying mechanisms and the improved classifications of scleroderma subtypes, treatments can be better personalized. Improving scleroderma patients' early diagnosis before end organ manifestations occur should imp...

journal_title：Archives of dermatological research

authors： Brady SM,Shapiro L,Mousa SA

更新日期：2016-09-01 00:00:00

abstract：:Thymocyte selection-associated high-mobility group box (TOX) is aberrantly expressed in cutaneous T-cell lymphomas. In a recent study, TOX expression was noted unexpectedly in the follicle center (germinal center) B-cells of reactive lymph nodes and tonsils, used as external controls. To evaluate whether TOX is also e...

journal_title：Archives of dermatological research

authors： Schrader AM,Jansen PM,Willemze R

更新日期：2016-08-01 00:00:00

abstract：:Interleukin-33 is a novel and an unconventional member of IL-1 family. It is an inflammation-induced factor with dual function exercising its role as an intracellular regulator of gene expression, as well as, an extracellular alarm mediator. It is a ligand for ST2, a heterodimeric membrane-bound receptor of the orphan...

journal_title：Archives of dermatological research

authors： Balato A,Raimondo A,Balato N,Ayala F,Lembo S

更新日期：2016-07-01 00:00:00

abstract：:Infantile hemangioma (IH), the most common tumor of infancy, is characterized by rapid growth during infancy, followed by spontaneous involution over 5-10 years. Certain clinical observations have led to the suggestion that IH is triggered and maintained by hypoxia. We review the literature on the possible role of hyp...

journal_title：Archives of dermatological research

authors： de Jong S,Itinteang T,Withers AH,Davis PF,Tan ST

更新日期：2016-05-01 00:00:00

abstract：:Oxidative stress may play a pivotal role in the pathogenesis of psoriasis, an inflammatory/hyperproliferative skin disease characterized by the cutaneous accumulation of neutrophils releasing reactive oxygen species, as revealed in a number of studies. This study was performed to demonstrate the presence of oxidative ...

journal_title：Archives of dermatological research

authors： Yazici C,Köse K,Utaş S,Tanrikulu E,Taşlidere N

更新日期：2016-04-01 00:00:00

abstract：:Bullous pemphigoid (BP) is an autoimmune blistering skin disease associated with autoantibodies against two hemidesmosomal proteins, BP180 (type XVII collagen) and BP230. As the pathogenic relevance of antibodies against the immunodominant NC16A domain of BP180 has been clearly demonstrated, specific removal of these ...

journal_title：Archives of dermatological research

authors： Mersmann M,Dworschak J,Ebermann K,Komorowski L,Schlumberger W,Stöcker W,Zillikens D,Probst C,Schmidt E

更新日期：2016-01-01 00:00:00

abstract：:The injured skin produces a number of mediators that directly or indirectly modulate cell chemotaxis, migration, proliferation, and angiogenesis. Components of the kinin pathway including the kinin B1 receptor (B1R) have been found to occur in the human skin, but information about its role on keratinocyte biology is s...

journal_title：Archives of dermatological research

authors： Mejia AJ,Matus CE,Pavicic F,Concha M,Ehrenfeld P,Figueroa CD

更新日期：2015-11-01 00:00:00

abstract：:Cutaneous adverse drug reactions (ADRs) are common. However, no prospective study assessing cutaneous ADRs is available for Chinese populations. This study aimed to assess the incidence, manifestations, causative drugs, and other factors related to cutaneous ADRs. A total of 22,866 inpatients were surveyed prospective...

journal_title：Archives of dermatological research

authors： Tian XY,Liu B,Shi H,Zhao ZR,Zhou XP,Zhang T,Sun QN,Zuo YG

更新日期：2015-11-01 00:00:00

abstract：:Melanoma incidence in Australia remains the highest in the world; hence understanding its causation is paramount for future therapeutic developments. Multiple primary melanomas are also common occurrences among the Australian population with identified risk factors such as personal and family history of melanoma, fair...

journal_title：Archives of dermatological research

authors： Sinnya S,Jagirdar K,De'Ambrosis B,McMeniman E,Sturm RA,Soyer HP

更新日期：2015-10-01 00:00:00

abstract：:About 5% of all cutaneous squamous cell carcinomas (cSCCs) metastasize, which is the principal cause of death by this type of cancer. However, to date there are no reliable biomarkers that categorize those SCC patients that will progress to metastasis. Nuclear active IKKα diminishes Maspin levels in prostate cancer fa...

journal_title：Archives of dermatological research

authors： Toll A,Margalef P,Masferrer E,Ferrándiz-Pulido C,Gimeno J,Pujol RM,Bigas A,Espinosa L

更新日期：2015-10-01 00:00:00

abstract：:Numerous reports have shown that psoriasis is associated with obesity and leptin. However, few reports are available on the association between serum leptin levels and leptin gene expression in SAT of psoriasis patients. To clarify this point, we examined serum leptin levels and expression levels of leptin messenger R...

journal_title：Archives of dermatological research

authors： Mitsuyama S,Abe F,Kimura M,Yoshida M,Higuchi T

更新日期：2015-08-01 00:00:00

abstract：:Organ size regulation is a highly coordinated process involving complex mechanisms. Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif, also known as WWTR1 (TAZ) have recently been linked to organ size determination and cell proliferation. Pilomatrixoma (PM) is a benign tumor of the a...

journal_title：Archives of dermatological research

authors： Cappellesso R,Bellan A,Saraggi D,Salmaso R,Ventura L,Fassina A

更新日期：2015-05-01 00:00:00

abstract：:Antihistamines are the first-line treatment for chronic urticaria (CU). However, some CU patients are relatively refractory to antihistamines. The mechanism underlying the interindividual variation is still unknown. The α-chain of the high-affinity IgE receptor is crucial to the IgE-mediated allergic response. The pre...

journal_title：Archives of dermatological research

authors： Guo A,Zhu W,Zhang C,Wen S,Chen X,Chen M,Zhang J,Su J,Chen W,Zhao Y,Yan S,He Y,Liu Z,Zhou H,Chen X,Li J

更新日期：2015-03-01 00:00:00

abstract：:Studies aimed at understanding the pathology, genetics, and therapeutic response of vitiligo rely on asking a single question about 'physician-diagnosed' vitiligo on surveys to identify subjects for research. However, this type of self-reporting is not sufficient. Our objective was to determine if the patient-administ...

journal_title：Archives of dermatological research

authors： Sheth VM,Gunasekera NS,Silwal S,Qureshi AA

更新日期：2015-01-01 00:00:00

abstract：:Annexin A1 deregulation is often associated with cancer. Indeed we have shown that annexin A1 is overexpressed in melanoma and promotes metastases by formyl peptide receptor stimulation and MMP2 expression. Here, we demonstrated in different melanoma cell lines that annexin A1-MMP2 induction is mediated by MAPK and ST...

journal_title：Archives of dermatological research

authors： Boudhraa Z,Merle C,Mazzocut D,Chezal JM,Chambon C,Miot-Noirault E,Theisen M,Bouchon B,Degoul F

更新日期：2014-12-01 00:00:00

abstract：:The mechanistic target of rapamycin (mTOR) is involved in the regulation of cellular growth, proliferation, lipid synthesis, and protein translation. The mTOR pathway involves two complexes: the mechanistic target of rapamycin complex 1 (mTORC1) and the mechanistic target of rapamycin complex 2 (mTORC2). Both mTOR com...

journal_title：Archives of dermatological research

authors： Leo MS,Sivamani RK

更新日期：2014-12-01 00:00:00

abstract：:To investigate the relationship between smoking and primary basal cell carcinoma (BCC), we analyzed data from a 16 year prospective study among randomly selected adults in Nambour, Queensland, Australia. Participants underwent a skin examination in 1992 and took part in an intervention study and follow-up. Information...

journal_title：Archives of dermatological research

authors： Hughes MC,Olsen CM,Williams GM,Green AC

更新日期：2014-11-01 00:00:00

abstract：:Diabetic foot ulcers (DFUs) are chronic wounds with high matrix metalloproteinase (MMP) activity, and are a frequent complication on diabetics. This work studied the expression of selected MMP and tissue inhibitor of metalloproteinases (TIMP) gene family members in DFU and normal skin biopsies, and in vitamin D-treate...

journal_title：Archives of dermatological research

authors： López-López N,González-Curiel I,Treviño-Santa Cruz MB,Rivas-Santiago B,Trujillo-Paez V,Enciso-Moreno JA,Serrano CJ

更新日期：2014-11-01 00:00:00

abstract：:Classic Refsum disease (RD) is a rare, autosomal recessively-inherited disorder of peroxisome metabolism due to a defect in the initial step in the alpha oxidation of phytanic acid (PA), a C16 saturated fatty acid with four methyl side groups, which accumulates in plasma and lipid enriched tissues (please see van den ...

journal_title：Archives of dermatological research

authors： Menon GK,Orsó E,Aslanidis C,Crumrine D,Schmitz G,Elias PM

更新日期：2014-10-01 00:00:00

abstract：:The use of underarm cosmetics is common practice in the Western society to obtain better body odor and/or to prevent excessive sweating. A survey indicated that 95 % of the young adult Belgians generally use an underarm deodorant or antiperspirant. The effect of deodorants and antiperspirants on the axillary bacterial...

journal_title：Archives of dermatological research

authors： Callewaert C,Hutapea P,Van de Wiele T,Boon N

更新日期：2014-10-01 00:00:00

abstract：:The calcipotriol/betamethasone dipropionate fixed-combination gel is widely used for topical treatment of psoriasis vulgaris. It has been hypothesized that calcipotriol counteracts glucocorticoid-induced skin atrophy which is associated with changes in the extracellular matrix (ECM). To elucidate the combined effects ...

journal_title：Archives of dermatological research

authors： Norsgaard H,Kurdykowski S,Descargues P,Gonzalez T,Marstrand T,Dünstl G,Røpke M

更新日期：2014-10-01 00:00:00

abstract：:All-trans retinoic acid (ATRA) is known to have beneficial effects on skin. It has been used extensively for the treatment of photodamaged skin. To assess the effects of all-trans retinoic acid on the dermis, specifically its effect on hyaluronate (hyaluronic acid, HA) synthesis and inhibition, tissue-engineered human...

journal_title：Archives of dermatological research

authors： Deshpande M,Papp S,Schaffer L,Pouyani T

更新日期：2014-09-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is believed to play a crucial role in neoplastic angiogenesis. Although the genetic background of basal cell carcinoma (BCC) has been analyzed in some papers, the mechanism of BCC pathogenesis is not fully understood. To the best of our knowledge, VEGF gene polymorphisms have ...

journal_title：Archives of dermatological research

authors： Sobjanek M,Zabłotna M,Lesiak A,Michajłowski I,Szczerkowska-Dobosz A,Sokolowska-Wojdylo M,Nowicki R

更新日期：2014-08-01 00:00:00

abstract：:Permeation enhancers are defined as substances that are capable of promoting penetration of drugs into skin and transdermal therapeutic systems offers a more reliable mean of administering drug through the skin. Skin is a natural barrier so it is necessary to employ enhancement strategies to improve topical bioavailab...

journal_title：Archives of dermatological research

authors： Patil UK,Saraogi R

更新日期：2014-07-01 00:00:00

abstract：:It has been suggested that free fatty acids (FFA) such as palmitate, which are secreted from enlarged adipocytes in the subcutaneous fat of obese subjects, serve as a link between obesity and altered skin functions. Cyclooxygenease-2 (COX-2) and prostanoids participate in the induction of impaired dermal function. In ...

journal_title：Archives of dermatological research

authors： Oh E,Yun M,Kim SK,Seo G,Bae JS,Joo K,Chae GT,Lee SB

更新日期：2014-05-01 00:00:00

abstract：:Atopic dermatitis (AD) is a frequent and burdensome disease. The objectives of this study were (1) to assess the willingness to pay (WTP) and quality of life (Qol) in AD patients and (2) to compare the results with data on other chronic skin diseases. To collect data, a non-interventional, cross-sectional nationwide p...

journal_title：Archives of dermatological research

authors： Beikert FC,Langenbruch AK,Radtke MA,Kornek T,Purwins S,Augustin M

更新日期：2014-04-01 00:00:00

abstract：:Bromodeoxyuridine (BrdU) has commonly been used for detecting of label-retaining cells (LRCs). To determine if there are LRCs and the distributions of LRCs in eccrine sweat glands, 20 newborn SD rats within 24 h after birth were injected intraperitoneally with 50 mg/kg/time BrdU four consecutive times at 2-h intervals...

journal_title：Archives of dermatological research

authors： Chen L,Zhang M,Li H,Tang S,Fu X

更新日期：2014-03-01 00:00:00

abstract：:We conducted a nationwide record-linked study using all English NHS hospital admission data and mortality statistics from 1999 to 2011 to evaluate the risk of concurrent or subsequent bullous pemphigoid (BP) in a cohort of 2,873,720 individuals with malignant cancers, when compared with a reference cohort. We calculat...

journal_title：Archives of dermatological research

authors： Ong E,Goldacre R,Hoang U,Sinclair R,Goldacre M

更新日期：2014-01-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) and activins are phylogenetically conserved proteins, belonging to the transforming growth factor-β superfamily, that signal through the phosphorylation of receptor-regulated Smad proteins, activating different cell responses. They are involved in various steps of skin morphogenesis ...

journal_title：Archives of dermatological research

authors： Moura J,da Silva L,Cruz MT,Carvalho E

更新日期：2013-09-01 00:00:00

abstract：:Antimicrobial peptides and proteins (AMPs) play important roles in skin immune defense due to their capacity to inhibit growth of microbes. During intrauterine life, the skin immune system has to acquire the prerequisites to protect the newborn from infection in the hostile environment after birth, which includes the ...

journal_title：Archives of dermatological research

authors： Schuster C,Gläser R,Fiala C,Eppel W,Harder J,Schröder JM,Elbe-Bürger A

更新日期：2013-08-01 00:00:00

abstract：:Psoriasis was initially considered to represent a disease of abnormal epidermal keratinocyte proliferation. Proliferation of keratinocytes is restricted by apoptotic cell death to maintain a constant thickness of epidermis. Nucleosomes are mainly released by apoptotic cells. Tumor necrosis factor-α (TNF-α) is an impor...

journal_title：Archives of dermatological research

authors： Dilek AR,Dilek N,Saral Y,Yüksel D

更新日期：2013-08-01 00:00:00

abstract：:Dimethylfumarate (DMF), the essential ingredient of the drug product Fumaderm®, is used to treat psoriasis with a recognized favorable long-term safety profile. Interestingly, the mode of action and the pharmacokinetics of DMF in psoriasis or multiple sclerosis are not fully explored. It is known that DMF as an α,β-un...

journal_title：Archives of dermatological research

authors： Dibbert S,Clement B,Skak-Nielsen T,Mrowietz U,Rostami-Yazdi M

更新日期：2013-07-01 00:00:00